Sevoflurane
Baxter
14
  • Description

Australian Approved Name: Sevoflurane

• Non-proprietary name: fluoromethyl 2,2,2,-trifluoro-1-(trifluoromethyl) ethyl ether

Sevoflurane is a clear, colourless, stable liquid containing no additives or chemical stabilizers. Sevoflurane is nonpungent. It is miscible with ethanol, ether, chloroform and petroleum benzene, and it is slightly soluble in water.

Anaesthetic inhalation:


Sevoflurane (C4H3F7O), volatile liquid for inhalation, a non-flammable and nonexplosive liquid administered

by vaporization, is a halogenated general inhalation anaesthetic drug.

Sevoflurane is stable when stored under normal room lighting conditions according to instructions.

Sevoflurane is chemically stable. No discernible degradation occurs in the presence of strong acids or heat.

The only known degradation reaction in the clinical setting is through direct contact with CO2 absorbents

(soda lime and Baralyme) producing pentafluoroisopropenyl fluoromethyl ether, (PIFE, C4H2F6O), also

known as Compound A, and trace amounts of pentafluoromethoxy isopropyl fluoromethyl ether, (PMFE,

C5H6F6O), also known as Compound B.

The production of degradants in the anesthesia circuit results from the extraction of the acidic proton in the

presence of a strong base (KOH and/or NaOH) forming an alkene (Compound A) from sevoflurane similar to

formation of 2-bromo-2-chloro-1,1-difluoro ethylene (BCDFE) from halothane. Baralyme causes more

production of Compound A than does soda lime. Laboratory simulations have shown that the concentration

of these degradants is inversely correlated with the fresh gas flow rate.

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